Atherosclerotic cardiovascular disease results in >19 million deaths annually, and coronary
heart disease accounts for the majority of this toll. Despite major advances in treatment of …

OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous
mechanism for intercellular communication. Since the discovery that EVs are capable of …

Human ESC-derived mesenchymal stem cell (MSC)-conditioned medium (CM) was previously
shown to mediate cardioprotection during myocardial ischemia/reperfusion injury through …

Very few genetic variants have been associated with depression and neuroticism, likely
because of limitations on sample size in previous studies. Subjective well-being, a phenotype …

We have previously identified exosomes as the paracrine factor secreted by mesenchymal
stem cells. Recently, we found that the key features of reperfusion injury, namely loss of ATP/…

Although paracrine effects of mesenchymal stem cells (MSCs) have been suggested previously,
cardioprotection by human MSC secretions has never been demonstrated. Human MSC…

Atherosclerotic luminal narrowing is determined by plaque mass and the mode of
geometrical remodeling. Recently, we reported that the type of atherosclerotic remodeling is …

In normal arteries, remodeling is a homeostatic response to changes in the flow and
circumferential stretch to restore normal shear stress and wall tension, respectively. 12 Outward …

Background: Rupture and erosion of advanced atherosclerotic lesions with a resultant
myocardial infarction or stroke are the leading worldwide cause of death. However, we have a …