The delay in childbearing is an important societal change contributing to an increasing
incidence of subfertility. The prevailing concept of female reproductive ageing assumes that the …

We report array-CGH screening of 95 syndromic patients with normal G-banded karyotypes
and at least one of the following features: mental retardation, heart defects, deafness, obesity…

We present an overview of the role of germline copy number variations (CNVs) in cancer
predisposition. CNVs represent a significant source of genetic diversity, although the …

Adult polycystic kidney disease (APCKD) is a common and often lethal multi-organ disease
with an autosomal dominant pattern of inheritance; approximately 1 in 1,000 people carry the …

We have studied 34 Becker and 160 Duchenne muscular dystrophy (DMD) patients with the
dystrophin cDNA, using conventional blots and FIGE analysis. One hundred twenty-eight …

Domesticated animal species such as dogs and cats, with their many different characteristics
and breed-specific diseases, and their close relationship and shared environment with …

BACKGROUND: Environmental factors explain only a small part of the age variance at
which menopause commences. The variation in natural menopause is a trait predominantly …

Overexpression of the gene encoding the β–amyloid precursor protein (APP) may have a key
role in the pathogenesis of both Alzheimer's disease (AD) and Down Syndrome (DS). We …

A genome scan was performed on 164 Dutch affected sib pairs (ASPs) with attention-deficit/hyperactivity
disorder (ADHD). All subjects were white and of Dutch descent and were …

Objectives : The purpose of this study was to investigate whether a harmful cardiovascular
risk profile accelerates menopause. Background : Women with an early menopause are at an …