Autotaxin (ATX), or ecto-nucleotide pyrophosphatase/phosphodiesterase-2, is a secreted
lysophospholipase D (lysoPLD) that hydrolyzes extracellular lysophospholipids into the lipid …

In protein crystallography, much time and effort are often required to trace an initial model
from an interpretable electron density map and to refine it until it best agrees with the …

Autotaxin (ATX) is a secreted phosphodiesterase that produces the lipid mediator lysophosphatidic
acid (LPA). LPA acts through specific guanine-nucleotide-binding protein (G protein)-…

wARP is a procedure that substantially improves crystallographic phases (and subsequently
electron-density maps) as an additional step after density-modification methods such as …

The aim of ARP/wARP is improved automation of model building and refinement in
macromolecular crystallography. Once a molecular-replacement solution has been obtained, it is …

ARP/wARP is a software suite to build macromolecular models in X-ray crystallography
electron density maps. Structural genomics initiatives and the study of complex macromolecular …

Ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family members (ENPP1–7)
have been implicated in key biological and pathophysiological processes, including …

Publisher Summary This chapter presents phase improvement, coupled with automated
map interpretation and model building, as one unified process within the framework of the …

Background: Chitinases cleave the β–1-4-glycosidicbond between the N–acetyl–D–glucosamine
units of which chitin is comprised. Chitinases are present in plants, bacteria and fungi, …

Artificial intelligence-based protein structure prediction approaches have had a transformative
effect on biomolecular sciences. The predicted protein models in the AlphaFold protein …