The diverse functions of microRNAs in animal development and disease
WP Kloosterman, RHA Plasterk - Developmental cell, 2006 - cell.com
MicroRNAs (miRNAs) control gene expression by translational inhibition and destabilization
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …
of mRNAs. While hundreds of miRNAs have been found, only a few have been studied in …
[HTML][HTML] MicroRNA function in animal development
E Wienholds, RHA Plasterk - FEBS letters, 2005 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate
gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified …
gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified …
Approaches to microRNA discovery
MicroRNAs (miRNAs) are noncoding RNAs that can regulate gene expression. Several
hundred genes encoding miRNAs have been experimentally identified in animals, and many …
hundred genes encoding miRNAs have been experimentally identified in animals, and many …
[HTML][HTML] Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi
F Simmer, M Tijsterman, S Parrish, SP Koushika… - Current biology, 2002 - cell.com
RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1].
Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss of function of a putative …
Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss of function of a putative …
Genome-Wide RNAi of C. elegans Using the Hypersensitive rrf-3 Strain Reveals Novel Gene Functions
F Simmer, C Moorman, AM Van Der Linden, E Kuijk… - PLoS …, 2003 - journals.plos.org
RNA-mediated interference (RNAi) is a method to inhibit gene function by introduction of
double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of …
double-stranded RNA (dsRNA). Recently, an RNAi library was constructed that consists of …
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegans
RF Ketting, SEJ Fischer, E Bernstein… - Genes & …, 2001 - genesdev.cshlp.org
Double-stranded RNAs can suppress expression of homologous genes through an
evolutionarily conserved process named RNA interference (RNAi) or post-transcriptional gene …
evolutionarily conserved process named RNA interference (RNAi) or post-transcriptional gene …
Processing of primary microRNAs by the Microprocessor complex
Mature microRNAs (miRNAs) are generated via a two-step processing pathway to yield ∼22-nucleotide
small RNAs that regulate gene expression at the post-transcriptional level 1 . …
small RNAs that regulate gene expression at the post-transcriptional level 1 . …
MicroRNA expression in zebrafish embryonic development
E Wienholds, WP Kloosterman, E Miska… - Science, 2005 - science.org
MicroRNAs (miRNAs) are small noncoding RNAs, about 21 nucleotides in length, that can
regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by …
regulate gene expression by base-pairing to partially complementary mRNAs. Regulation by …
On the role of RNA amplification in dsRNA-triggered gene silencing
T Sijen, J Fleenor, F Simmer, KL Thijssen, S Parrish… - Cell, 2001 - cell.com
We have investigated the role of trigger RNA amplification during RNA interference (RNAi)
in Caenorhabditis elegans. Analysis of small interfering RNAs (siRNAs) produced during …
in Caenorhabditis elegans. Analysis of small interfering RNAs (siRNAs) produced during …
[HTML][HTML] Phylogenetic shadowing and computational identification of human microRNA genes
We sequenced 122 miRNAs in 10 primate species to reveal conservation characteristics of
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …
miRNA genes. Strong conservation is observed in stems of miRNA hairpins and increased …