The ‘insulin superfamily’ is an ancient category of small, structurally related proteins, such
as insulin, insulin-like growth factors (IGF) and relaxin. Insulin-like signaling molecules have …

BACKGROUND Infertility is an important side effect of treatments used for cancer and other
non-malignant conditions in males. This may be due to the loss of spermatogonial stem cells (…

AMP‐activated protein kinase (AMPK) is an evolutionarily conserved cellular switch that
activates catabolic pathways and turns off anabolic processes. In this way, AMPK activation can …

As a first step toward the exploitation of the disaccharide trehalose as a stress-protective
and preservative agent in plants, we engineered trehalose biosynthesis in tobacco (Nicotiana …

The multifunctional AMPK-activated protein kinase (AMPK) is an evolutionarily conserved
energy sensor that plays an important role in cell proliferation, growth, and survival. It remains …

Bursicon is a neurohumoral agent responsible for tanning and hardening of the cuticle and
expansion of the wings during the final phase of insect metamorphosis. Although the …

STUDY QUESTION Does vitrification of human immature testicular tissue (ITT) have potential
benefits for future fertility preservation? Does vitrification of human ITT have potential …

OBJECTIVE: To assess vitrification of prepubertal human testicular tissue in vitro. DESIGN:
Case report. SETTING: Academic research unit. PATIENT(S): Two patients (6 and 12 years of …

STUDY QUESTION Is an organotypic culture system able to provide the appropriate
testicular microenvironment for in-vitro maturation of human immature testicular tissue (ITT)? …

Members of the tachykinin peptide family have been well conserved during evolution and are
mainly expressed in the central nervous system and in the intestine of both vertebrates and …