This article reviews research into the possible significance of disorders of the central 5-HT
metabolism in the pathogenesis of recurrent depressions. The available data would seem to …

: Over the past 15 years several clinical studies have been published dealing with the
hypothesis that disturbances in central serotonergic functioning could be related to outward …

The influence of iv administered probenecid on the 5-HIAA concentration in the CSF was
studied in a group of patients with vital (“endogenous”) depression and a non-depressive …

It was demonstrated that the influence of iv administered probenecid on HVA concentration
in CSF was less pronounced in a group of retarded depression than in a group of non-…

Over the past decades the rate of completed suicide has remained quite stable, that of
suicide attempts even seems to have increased (to the extent it has been studied in defined …

The probenecid technique was used in a study of the central dopamine DA metabolism in
patients with depressions, psychotic disorders, and Parkinson's disease. The disturbances …

In depressions, varying therapeutic effects have been obtained with 5-HT precursors. This is
possibly due to the fact that the group of the depressions is pathogenetically heterogeneous…

Notes that over the past decades, the rate of completed suicide has remained quite stable,
whereas that of suicide attempts seems to have increased (to the extent it has been studied in …

This article discusses the results of recent neuroendocrinological research in depressions.
The abnormalities found in a given category of vital depressive patients ‐ cortisol …

1. Central dopamine turnover may be lowered in patients with unipolar endogenous depression
particularly when associated with retardation. 2. Nomifensine selectively activates the …