Cytokines are key components of the innate and adaptive immune system. As pivotal players
in the progression or regression of a pathological process, these molecules provide a …

Heat shock proteins (Hsps) are remarkably immunogenic, despite their high degree of
evolutionary conservation. Experimental and clinical observations on autoimmune diseases …

Since the discovery of FOXP3 + regulatory T (T REG ) cells over 15 years ago, intensive
research has focused on their presence, phenotype and function in autoimmune disease. …

Cytokines secreted by cells of the immune system can alter the behavior and properties of
immune or other cells. At a site of inflammation, sets of cytokines interact with immune cells, …

Background Growing knowledge about cellular interactions in the immune system, including
the central role of cytokine networks, has lead to new treatments using monoclonal …

Background: Juvenile idiopathic arthritis (JIA) consists of a heterogeneous group of disorders
with, for the most part, an unknown immunopathogenesis. Although onset and disease …

Regulatory T cells (Tregs) are a specific subset of lymphocytes that are critical for the
maintenance of self-tolerance. Expression levels of the transcription factor Foxp3 have been …

Stable Foxp3 expression is required for the development of functional regulatory T (Treg)
cells. Here, we demonstrate that the expression of the transcription factor Foxp3 can be …

… De Jager W, Hoppenreijs EP, Wulffraat NM, Wedderburn LR, Kuis W, Prakken BJ. Blood
and synovial fluid cytokine signatures in patients with juvenile idiopathic arthritis: a cross-…

Cytokines, chemokines and soluble adhesion molecules interact in a complex network within
the immune system. Fingerprinting of these proteins may allow the use of these proteins as …