Streptococcus pneumoniae is a major cause of morbidity and mortality in infants, children and
the elderly. Despite the availability of excellent antimicrobial therapy and adequate health …

In laboratory animals, an adequate way to assess effects of environmental exposures on the
immune system is to study effects on antigen-specific immune responses, such as after …

A trial with a 7-valent pneumococcal-conjugate vaccine in children with recurrent acute otitis
media showed a shift in pneumococcal colonisation towards non-vaccine serotypes and an …

We analyzed pertussis reporting, death, hospitalization, and serodiagnostic data from 1976
to 1998 to help explain the cause of the 1996 pertussis outbreak in the Netherlands. The …

… Labadie J, Sundermann LC, Rümke HC, and the DTPIPV~Hib vaccine study group. Multi-center
study on the simultaneous administration of DTP-IPV and Hib PRP-T vaccines. Part 1. …

BACKGROUND: The MMRV combination vaccine, Priorix-Tetra™, is currently licensed in
several European countries using a two-dose schedule in infants aged ≥9 months, with a …

To study the reactogenicity and immunogenicity of a hexavalent meningococcal outer-membrane-vesicle
vaccine (OMV), two different dosages of this vaccine (7.5 and 15 μg of …

This randomized, double-blind study evaluated concomitant administration of 13-valent
pneumococcal conjugate vaccine (PCV13) and trivalent inactivated influenza vaccine (TIV) in …

Context: The prevalence of allergic diseases has increased considerably over the last
decades. The hygiene hypothesis has emerged, linking reduced microbial exposure and …

In 1941, HC Rumke, Professor of Psychiatry in Utrecht, published his study on’The nuclear
symptom of schizophrenia and the praecoxfeeling’. The conclusion at which he arrives in this …