The TOR (target of rapamycin) pathway is an evolutionarily conserved signaling module
regulating cell growth (accumulation of mass) in response to a variety of environmental cues …

Background Recent attention in health care has been on the actual architectural design of a
hospital facility, including its technology and equipment, and its effect on patient safety. To …

The proto-oncogene KRAS is mutated in a wide array of human cancers, most of which are
aggressive and respond poorly to standard therapies. Although the identification of specific …

Mammalian target of rapamycin (mTOR) is a central regulator of protein synthesis whose
activity is modulated by a variety of signals. Energy depletion and hypoxia result in mTOR …

The physical environment has a significant impact on health and safety; however, hospitals
have not been designed with the explicit goal of enhancing patient safety through facility …

Dysregulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway occurs frequently
in human cancer. PTEN tumor suppressor or PIK3CA oncogene mutations both direct PI3K…

Diverse extrinsic and intrinsic cues must be integrated within a developing organism to ensure
appropriate growth at the cellular and organismal level. In Drosophila, the insulin receptor/…

ContextStudies with positive results are more likely to be published than studies with negative
results (publication bias). One reason this occurs is that authors are less likely to submit …

This book is different from its predecessor on Mark in that it does not deal with problems of
text and punctuation. The edition of The Greek New Testament (GNT) with its extensive critical …

Aberrant expression of MYC transcription factor family members predicts poor clinical outcome
in many human cancers. Oncogenic MYC profoundly alters metabolism and mediates an …