To further elucidate the role of the Na + channel in the ischemic accumulation of intracellular
Na + (Na + i ), 200μmlidocaine was included in the perfusate for 5 min prior to 30 min of …

The effect of Danshen (Radix salviae miltiorrhizae) on mechanical activity and coronary flow
rate if isolated rat hearts was examined to assess the ability of Danshen to protect the …

Accumulation of sodium-ions (Na + ) in myocardial cells during both ischemia and calcium (Ca
2+ )-free perfusion has been suggested to play an important role in the damage occurring …

… 24 van Binsbergen XA, van Emous JG, Ferrari R, van Echteld CJA, Ruigrok TJC. Metabolic
and functional consequences of successive no-flow and sustained low-flow ischaemia: a 31 …

Reperfusion of isolated rat hearts with Ca 2+ -containing medium, after a short Ca 2+ -free
perfusion period, results in irreversible cell damage (calcium paradox). In this study this type …

Limited time resolution has hampered proper evaluation of changes in intracellular Na + (Na
+ i ) in whole hearts upon post-ischemic reperfusion. In isolated rat hearts perfused at 37C, …

Magnesium (Mg 2+ ) is an important regulator of cell energy metabolism, since only MgATP
can serve as a substrate for ATP utilizing processes. We used 31 P NMR spectroscopy to …

The term ‘hibernation’has been borrowed from zoology and implies an adaptive reduction of
energy expenditure through reduced activity in a situation of reduced energy supply. In the …

In vivo 31 P-NMR was used to measure the effects of the anti-tumor drug adriamycin on the
energy metabolism of rat heart. The exclusive acquisition of NMR signal from cardiac muscle …

Experiments were carried out to test the hypothesis that membrane injury associated with Ca
2+ depletion of the heart is involved in the development of Ca 2+ overload during the Ca 2+ …