Mood disorders collectively account for a substantial proportion of disease burden across the
globe and have a devastating impact on quality of life and occupational function. Here we …

Obsessive-compulsive disorder (OCD) is a common, heritable and disabling neuropsychiatric
disorder. Theoretical models suggest that OCD is underpinned by functional and structural …

… 4 Sahakian BJ. Owen AM: Computerised assessн ment in neuropsychiatry using CANTAB.
… Sahakian BJ, Robн bins TW: Visuospatial memory deficits at difн ferent stages of Parkinson's …

Cognitive functions dependent on the prefrontal cortex, such as the ability to suppress behavior
(response inhibition) and to learn from complex feedback (probabilistic learning), play …

Obsessive-compulsive disorder (OCD) is characterized by repetitive thoughts and
behaviors associated with underlying dysregulation of frontostriatal circuitry. Central to …

Groups of patients with dementia of Alzheimer type (DAT) and idiopathic Parkinson's
disease, together with age and IQ-matched normal controls, were compared on several …

This paper illustrates how recent developments in computing technology can be exploited
for the neuropsychological assessment ofneurodegenerative diseases. Computerizedtests …

We used a novel computerized decision-making task to compare the decision-making behavior
of chronic amphetamine abusers, chronic opiate abusers, and patients with focal lesions …

The precise localization of executive functions such as response inhibition within the prefrontal
cortex (PFC), although theoretically crucial, has proven to be controversial and difficult 1 . …

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