As more recombinant human proteins become available on the market, the incidence of
immunogenicity problems is rising. The antibodies formed against a therapeutic protein can …

The expiry of the first patents for recombinant-DNA-derived biopharmaceuticals will open
the possibility of marketing generics, if they can be shown to be essentially similar to the …

Background: Therapeutic proteins have revolutionized the treatment of many diseases. In
the near future, many more therapeutic proteins are likely to become available for an …

Hepatitis delta (δ) virus (HDV), a satellite virus of the hepatitis B virus (HBV), causes a
severe form of viral hepatitis in humans 1 . Here we present evidence based on electron …

This study was designed to test the hypothesis that T-cell effector mechanisms are required
for protective immunity to malaria sporozoites. Administration of neutralizing monoclonal …

… Schellekens H. Immunogenicity of therapeutic proteins. Nephrol Dial Transplant 2003; 18: …
Schellekens H. Relationship between biopharmaceutical immunogenicity of epoetin alfa and …

Changes in microbial diversity and composition are increasingly associated with several
disease states including obesity and behavioural disorders. Obesity-associated microbiota alter …

Does it matter what we eat for our mental health? Accumulating data suggests that this may
indeed be the case and that diet and nutrition are not only critical for human physiology and …

Context Biologicals are a relatively new class of medicines that carry specific risks (eg,
immunogenicity). However, limited information is available on the nature and timing of safety …

The complex bidirectional communication between the gut and the brain is finely orchestrated
by different systems, including the endocrine, immune, autonomic, and enteric nervous …