The study of metal complexes for the treatment of cancer diseases has resulted in the
identification of some unique properties of ruthenium-based compounds. Among these inorganic-…

Learning Objectives After completing this course, the reader will be able to: Discuss the safety
and side effects of PDT. Identify appropriate indications for PDT. Explain the choice of PDT …

The liver is the predominant organ in which biotransformation of foreign compounds takes
place, although other organs may also be involved in drug biotransformation. Ideally, an in …

Background and Methods: Breast cancer resistance protein (BCRP/MXR/ABCP) is a
multidrug-resistance protein that is a member of the adenosine triphosphate-binding cassette family …

Background The inhibition of poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP)
is a potential synthetic lethal therapeutic strategy for the treatment of cancers with specific …

PURPOSE: We discovered that breast cancer resistance protein (BCRP), a recently identified
adenosine triphosphate–binding cassette drug transporter, substantially limits the oral …

… DD, van der Valk P., Dalton WS, Schellens JHM, Scheper RJ BCRP is localized at the plasma
… Meerum Terwogt JM, Beijnen JH, ten Bokkel Huinink WW, Rosing H., Schellens JHM Co-…

Background Patients with metastatic colorectal cancer with the BRAF V600E mutation have
a poor prognosis, with a median overall survival of 4 to 6 months after failure of initial therapy…

Purpose Selective tumor cell cytotoxicity can be achieved through a synthetic lethal strategy
using poly (ADP)-ribose polymerase (PARP) inhibitor therapy in BRCA1/2 mutation carriers …

Purpose: NAMI-A {H 2 Im[trans-RuCl 4 (DMSO)HIm] or imidazolium-trans-DMSO-imidazole-tetrachlororuthenate}
is a novel ruthenium-containing compound that has demonstrated …