Extracellular vesicles for drug delivery
P Vader, EA Mol, G Pasterkamp… - Advanced drug delivery …, 2016 - Elsevier
Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous
mechanism for intercellular communication. Since the discovery that EVs are capable of …
mechanism for intercellular communication. Since the discovery that EVs are capable of …
Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment
Curcumin, a natural yellow phenolic compound, is present in many kinds of herbs,
particularly in Curcuma longa Linn. (turmeric). It is a natural antioxidant and has shown many …
particularly in Curcuma longa Linn. (turmeric). It is a natural antioxidant and has shown many …
[HTML][HTML] Extracellular vesicles as drug delivery systems: Why and how?
OM Elsharkasy, JZ Nordin, DW Hagey… - Advanced drug delivery …, 2020 - Elsevier
Over the past decades, a multitude of synthetic drug delivery systems has been developed
and introduced to the market. However, applications of such systems are limited due to …
and introduced to the market. However, applications of such systems are limited due to …
Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
RM Schiffelers, A Ansari, J Xu, Q Zhou… - Nucleic acids …, 2004 - academic.oup.com
Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the
ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, …
ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, …
In vivo imaging reveals extracellular vesicle-mediated phenocopying of metastatic behavior
A Zomer, C Maynard, FJ Verweij, A Kamermans… - Cell, 2015 - cell.com
Most cancer cells release heterogeneous populations of extracellular vesicles (EVs) containing
proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead …
proteins, lipids, and nucleic acids. In vitro experiments showed that EV uptake can lead …
Obstacles and opportunities in the functional analysis of extracellular vesicle RNA–an ISEV position paper
The release of RNA-containing extracellular vesicles (EV) into the extracellular milieu has
been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids…
been demonstrated in a multitude of different in vitro cell systems and in a variety of body fluids…
Cellular stress conditions are reflected in the protein and RNA content of endothelial cell-derived exosomes
Background: The healthy vascular endothelium, which forms the barrier between blood and
the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and …
the surrounding tissues, is known to efficiently respond to stress signals like hypoxia and …
PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time
SAA Kooijmans, LAL Fliervoet, R Van Der Meel… - Journal of Controlled …, 2016 - Elsevier
Extracellular vesicles (EVs) are increasingly being recognized as candidate drug delivery
systems due to their ability to functionally transfer biological cargo between cells. However, the …
systems due to their ability to functionally transfer biological cargo between cells. However, the …
RGD-based strategies for selective delivery of therapeutics and imaging agents to the tumour vasculature
During the past decade, RGD-peptides have become a popular tool for the targeting of drugs
and imaging agents to α v β 3 -integrin expressing tumour vasculature. RGD-peptides have …
and imaging agents to α v β 3 -integrin expressing tumour vasculature. RGD-peptides have …