Organoids derived from the liver have hepatocellular differentiation potential and can be an
unlimited source for hepatocytes for application in in vitro toxicology testing and for …

Background Hepatic progenitor cells (HPCs) hold a great potential for therapeutic
intervention for currently untreatable liver diseases. However, in human diseases molecular …

The recent development of 3D-liver stem cell cultures (hepatic organoids) opens up new
avenues for gene and/or stem cell therapy to treat liver disease. To test safety and efficacy, a …

Hepatic steatosis is a highly prevalent liver disease, yet research is hampered by the lack of
tractable cellular and animal models. Steatosis also occurs in cats, where it can cause …

The shortage of liver organ donors is increasing and the need for viable alternatives is urgent.
Liver cell (hepatocyte) transplantation may be a less invasive treatment compared with …

Objective Following chronic liver injury or when hepatocyte proliferation is impaired, ductular
reactions containing hepatic progenitor cells (HPCs) appear in the periportal regions and …

New therapeutic concepts developed in rodent models should ideally be evaluated in large
animal models prior to human clinical application. COMMD1-deficiency in dogs leads to …

The liver progenitor cell compartment in the normal canine liver and in spontaneous canine
acute (AH) and chronic hepatitis (CH) was morphologically characterised and compared to …

Background: When hepatocyte replication during liver disease is insufficient for regeneration,
liver progenitor cells (LPCs) are activated. The cells and stroma in the immediate …

New curative therapies for severe liver disease are urgently needed in both the human and
veterinary clinic. It is important to find new treatment modalities which aim to compensate for …