Collagens represent up to 40% of the total protein of the vessel wall, forming an insoluble
scaffold which is essential for tissue integrity and which provides a surface for the attachment …

Normal hemostasis is initiated by damage of the vessel wall with exposure of subendothelial
structures to flowing blood and results in the formation of a solid hemostatic plug. The first …

Platelet activation leads to secretion of granule contents and to the formation of microvesicles
by shedding of membranes from the cell surface. Recently, we have described small …

Department of Haematology, Utrecht University, Utrecht, and rBijvoet Centre for Biomolecular
Research, Utrecht, The Netherlands lntroduction a more gradual drop at higher shear rates …

ONE of the early events in the haemostatic process is the adherence of blood platelets to
collagen of the subendothelium. Subsequent platelet-to-platelet adhesion then leads to the …

Transient interactions of platelet-receptor glycoprotein Ibα (GpIbα) and the plasma protein
von Willebrand factor (VWF) reduce platelet velocity at sites of vascular damage and play a …

The interaction of blood platelets with collagen is generally considered to be of primary
importance in the arrest of bleeding and to have a role in the pathogenesis of thrombosis and …

BACKGROUND Nitric oxide (NO) has been identified as endothelium-derived relaxing factor
(EDRF), which, in addition to its relaxant effects on vascular smooth muscle cells, is also a …

To clone the CD63 antigen, originally described as a blood platelet activation marker, we
adapted the expression cloning procedure of Seed and Aruffo (Seed, B., and Aruffo, A. (1987) …

Hematocrit and vessel wall shear rate are important factors in the transport and subsequent
adherence of platelets to vessel wall subendothelium. When mass transport theory is …