Copper and human health: biochemistry, genetics, and strategies for modeling dose-response relationships
BR Stern, M Solioz, D Krewski, P Aggett… - Journal of Toxicology …, 2007 - Taylor & Francis
Copper (Cu) and its alloys are used extensively in domestic and industrial applications. Cu
is also an essential element in mammalian nutrition. Since both copper deficiency and …
is also an essential element in mammalian nutrition. Since both copper deficiency and …
Application of the Margin of Exposure (MOE) approach to substances in food that are genotoxic and carcinogenic
D Benford, PM Bolger, P Carthew, M Coulet… - Food and chemical …, 2010 - Elsevier
This paper presents the work of an expert group established by the International Life
Sciences Institute – European branch (ILSI Europe) to follow up the recommendations of an …
Sciences Institute – European branch (ILSI Europe) to follow up the recommendations of an …
Mathematical modelling and quantitative methods
L Edler, K Poirier, M Dourson, J Kleiner… - Food and Chemical …, 2002 - Elsevier
The present review reports on the mathematical methods and statistical techniques presently
available for hazard characterisation. The state of the art of mathematical modelling and …
available for hazard characterisation. The state of the art of mathematical modelling and …
Confidence limits for hazardous concentrations based on logistically distributed NOEC toxicity data
T Aldenberg, W Slob - Ecotoxicology and environmental safety, 1993 - Elsevier
This paper deals with the calculation of Hazardous Concentrations of toxic substances from
small sets of laboratory toxicity data, eg, NOECs. A procedure due to Van Straalen and …
small sets of laboratory toxicity data, eg, NOECs. A procedure due to Van Straalen and …
Gevoeligheidsanalyse en onzekerheidsanalyse: een inventarisatie van ideeen, methoden en technieken
PHM Janssen, W Slob… - RIVM Rapport …, 1990 - rivm.openrepository.com
Mathematical models are useful tools for studying many problems in the environmental and
public health area. For a reliable development and application of these models …
public health area. For a reliable development and application of these models …
Dose-response modeling of continuous endpoints
W Slob - Toxicological Sciences, 2002 - academic.oup.com
A family of (nested) dose-response models is introduced herein that can be used for describing
the change in any continuous endpoint as a function of dose. A member from this family …
the change in any continuous endpoint as a function of dose. A member from this family …
Update: use of the benchmark dose approach in risk assessment
EFSA Scientific Committee, A Hardy, D Benford… - EFSA …, 2017 - Wiley Online Library
The Scientific Committee ( SC ) reconfirms that the benchmark dose ( BMD ) approach is a
scientifically more advanced method compared to the NOAEL approach for deriving a …
scientifically more advanced method compared to the NOAEL approach for deriving a …
Endocrine effects of tetrabromobisphenol-A (TBBPA) in Wistar rats as tested in a one-generation reproduction study and a subacute toxicity study
LTM Van der Ven, T Van de Kuil, A Verhoef… - Toxicology, 2008 - Elsevier
Endocrine effects of the brominated flame retardant tetrabromobisphenol-A (TBBPA) were
studied in a one-generation reproduction assay in Wistar rats via repeated dietary exposure, …
studied in a one-generation reproduction assay in Wistar rats via repeated dietary exposure, …
A 28-day oral dose toxicity study enhanced to detect endocrine effects of hexabromocyclododecane in Wistar rats
LTM van der Ven, A Verhoef, T Van De Kuil… - Toxicological …, 2006 - academic.oup.com
A 28-day repeated dose study in rats (OECD407) enhanced for endocrine and immune
parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily …
parameters was performed with hexabromocyclododecane (HBCD). Rats were exposed by daily …
Uncertainty analysis in multiplicative models
W Slob - Risk analysis, 1994 - Wiley Online Library
Uncertainties are usually evaluated by Monte Carlo analysis. However, multiplicative models
with lognormal uncertainties, which are ubiquitous in risk assessments, allow for a simple …
with lognormal uncertainties, which are ubiquitous in risk assessments, allow for a simple …