Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

The purpose of this guideline is to present evidence-based and consensus-based recommendations
for the prevention and treatment of postoperative delirium. The cornerstones of the …

Background Intraoperative hypotension is a common side effect of general anaesthesia and
might lead to inadequate organ perfusion. It is unclear to what extent hypotension during …

Background Previous studies suggested a protective effect of smoking on Alzheimer's disease,
but most were case-control studies based on prevalent cases. The findings of prospective …

Objective: To update and expand the 2013 Clinical Practice Guidelines for the Management
of Pain, Agitation, and Delirium in Adult Patients in the ICU. Design:

Background Vascular disorders have been implicated in dementia, but whether atherosclerosis
is related to the most frequent type of dementia, Alzheimer's disease, is not known. The …

Importance One-year outcomes in patients who have had COVID-19 and who received
treatment in the intensive care unit (ICU) are unknown. Objective To assess the occurrence of …

Objective: Although numerous risk factors for delirium in the ICU have been proposed, the
strength of evidence supporting each risk factor remains unclear. This study systematically …

Objectives To develop and validate a delirium prediction model for adult intensive care
patients and determine its additional value compared with prediction by caregivers. Design …

Objectives To provide risk estimates of dementia and Alzheimer disease as a function of the
apolipoprotein E (APOE) genotypes and to assess the proportion of dementia that is …