Radiotherapy, an important treatment modality in oncology, kills cells through induction of
oxidative stress. However, malignant tumors vary in their response to irradiation as a …

The estrogen receptor a (ERa) is a ligand-dependent transcription factor that regulates a large
number of genes in many different target tissues and is important in the development and …

Hypoxia is an important feature of the microenvironment of a wide range of solid tumours. Its
critical role in radio- and chemoresistance and its significance as an adverse prognostic …

All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …

We analysed whole-genome sequences of 560 breast cancers to advance understanding of
the driver mutations conferring clonal advantage and the mutational processes generating …

Approximately 1–5% of breast cancers are attributed to inherited mutations in BRCA1 or
BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other …

Introduction The human genome is peppered with mobile repetitive elements called long
interspersed nuclear element–1 (L1) retrotransposons. Propagating through RNA and cDNA …

For interpretation of quantitative gene expression measurements in clinical tumor samples,
a normalizer is necessary to correct expression data for differences in cellular input, RNA …

We used ChIP‐Seq to map ERα‐binding sites and to profile changes in RNA polymerase II (RNAPII)
occupancy in MCF‐7 cells in response to estradiol (E2), tamoxifen or fulvestrant. …

Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a
Phase III Randomized Trial Page 1 Accelerated Radiotherapy With Carbogen and …