Solution NMR spectroscopy is an extremely powerful technology for the study of biomolecular
dynamics and site-specific molecular interactions. An important limitation in the past has …

A major goal in structural biology is to unravel how molecular machines function in detail. To
that end, solution-state NMR spectroscopy is ideally suited as it is able to study biological …

Highlights • Methyl NMR has enabled interaction studies of large protein complexes. • Using
methyl NMR binding sites can be accurately mapped and affinities determined. • Structures …

The machinery used by the cell to perform essential biological processes is made up of
large molecular assemblies. One such complex, the proteasome, is the central molecular …

Spinal muscular atrophy (SMA) is a common motor neuron disease that results from mutations
in the Survival of Motor Neuron (SMN) gene. The SMN protein plays a crucial role in the …

To elucidate the underlying mechanisms of the initial fall in blood pressure on standing upright
from the supine position, we measured the beat-to-beat changes in intra-arterial pressure …

The proteasome catalyzes the majority of protein degradation in the cell and plays an
integral role in cellular homeostasis. Control over proteolysis by the 20S core-particle (CP) …

During spliceosome assembly, splicing factor 1 (SF1) specifically recognizes the intron
branch point sequence (BPS) UACUAAC in the pre-mRNA transcripts. We show that the KH-…

The essential splicing factors SF1 and U2AF play an important role in the recognition of the
pre-mRNA 3′ splice site during early spliceosome assembly. The structure of the C-terminal …

The highly conserved, 300-kDa cylindrical protease ClpP is an important component of the
cellular protein quality machinery. It consists of 14 subunits arranged into two heptameric …