Tyrosine phosphorylation is an important regulatory mechanism in response to the action of
growth factors and oncogenes. Since many oncogenes code for tyrosine kinases, increased …

Purine nucleoside phosphorylase (PNP) deficiency is associated with a severe defect in
thymus-derived (T)-lymphocyte function combined with normal bone marrow-derived (B)-…

We studied a 15-month-old girl who had normal T-cell and B-cell immunity at birth, after
which a gradual decrease in T-cell immunity developed. This selective cellular …

… of pyruvate kinase in normal and neoplastic tissues; in Staal GEJ, Van Veelen CWM (eds): …
) as marker for neuro-endocrine tumors; in Staal GEJ, Van Veelen CWM (eds): Markers of …

Tyrosine specific protein kinase activity was determined in 70 specimens of the human
mammary gland. These included 28 cancers of the breast, 21 benign breast diseases, and 21 …

… 3 Verhagen JN, Van der Heiden MCM, Staal GEJ, et al: Pyruvate kinase in normal human
… 15 Van den Doel EMH, Rijksen G, Staal GEJ et al: Enolase isoenzymes in human gliomas. …

In this study, we investigated the alterations in the activity, subunit profile, and kinetic regulatory
properties of phosphofructokinase (PFK) from human gliomas compared with those from …

Red cell populations were fractionated on the basis of differences in density by a centrifugation
method described by Murphy and on the basis of differences in mean cell volume (MCV) …

Human erythrocyte hexokinase (ATP :d-hexose 6-phosphotransferase, EC 2.7.1.1) was
inhibited competitively with respect to MgATP 2− by glucose-6-P (K i = 10.8 μM) and fructose-6-P …

… Rijksen G, Staal GEJ: Properties of human erythrocyte hexokinase related to cell age. Clin
… Kraaijenhagen RJ, Rijksen G, Staal GEJ: Hexokinase isozyme distribution and regulatory …