In 1979, two categories of dopamine (DA) receptors (designated as D-1 and D-2) were
identified on the basis of the ability of a limited number of agonists and antagonists to …

2.2. Heterogeneity of the dopaminergic and cholinergic systems in the striatum 756 3.
MULTIPLICITY, DISTRIBUTION AND SIGNAL TRANSDUCTION ASPECTS OF DOPAMINE …

Parkinson’s disease (PD) is an idiopathic disease caused by necrosis and apoptosis of
dopaminergic cells in the brainstem, which are probably induced by oxidative stress. Current …

Two types of dopamine receptor whose stimulation affects cellular cyclic AMP have now been
identified. In tissues as different as insect ganglia and mammalian neostriatum, stimulation …

Olfactory dysfunction is a common finding in patients with Parkinson's disease (PD). As most
studies reported on odor identification in more advanced and treated PD, we administered …

Materials and Methods Radioligand receptor binding and neurotransmitter uptake assays:
inhibition by drugs Female Wistar rats (150 g) or male Pirbright guinea pigs (200 g) were …

OBJECTIVES: The main neuropathological feature in Parkinson's disease is a severe
degeneration of the dopaminergic neurons in the substantia nigra resulting in a loss of dopamine (…

By the time a clinical diagnosis of Parkinson's disease (PD) is made, a significant loss of
dopaminergic neurons has already occurred. Identifying patients in the period between the …

(3.79 ±0.67/3.82 ±0.74) and (4.16 ±0.70/4.08 ±0.97) for the ROI and VOI technique,
respectively. No significant differences were measured between test/retest studies. The mean …

Ten healthy subjects and 16 patients with early Parkinson’s disease (PD) were examined with
single photon emission computed tomography (SPECT) and [ 123 I]β-CIT, a ligand for the …