The biogenesis and functions of exosomes

W Stoorvogel, MJ Kleijmeer, HJ Geuze, G Raposo - Traffic, 2002 - Wiley Online Library
Exosomes are membrane vesicles with a diameter of 40–100 nm that are secreted by many
cell types into the extracellular milieu. They correspond to the internal vesicles of an …

Extracellular vesicles: exosomes, microvesicles, and friends

G Raposo, W Stoorvogel - Journal of Cell Biology, 2013 - rupress.org
Cells release into the extracellular environment diverse types of membrane vesicles of
endosomal and plasma membrane origin called exosomes and microvesicles, respectively. …

Biological properties of extracellular vesicles and their physiological functions

M Yáñez-Mó, PRM Siljander, Z Andreu… - Journal of …, 2015 - Taylor & Francis
In the past decade, extracellular vesicles (EVs) have been recognized as potent vehicles of
intercellular communication, both in prokaryotes and eukaryotes. This is due to their capacity …

[HTML][HTML] Proteomic and biochemical analyses of human B cell-derived exosomes: potential implications for their function and multivesicular body formation

R Wubbolts, RS Leckie, PTM Veenhuizen… - Journal of Biological …, 2003 - ASBMB
Exosomes are 60–100-nm membrane vesicles that are secreted into the extracellular milieu
as a consequence of multivesicular body fusion with the plasma membrane. Here we …

B lymphocytes secrete antigen-presenting vesicles.

G Raposo, HW Nijman, W Stoorvogel… - The Journal of …, 1996 - rupress.org
Antigen-presenting cells contain a specialized late endocytic compartment, MIIC (major
histocompatibility complex [MHC] class II-enriched compartment), that harbors newly …

Topography of glycosylation

HT Haigler, JA McKanna, S Cohen, S Felder, K Miller… - J. Cell Biol, 1979 - cell.com
FOUR DISTINCT TYPES of glycosylation are known to occur in the endoplasmic reticulum (ER)
of eukaryotic cells:(1) N-linked glycosylation of proteins involves the addition of a …

[HTML][HTML] Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

H Kalra, RJ Simpson, H Ji, E Aikawa, P Altevogt… - PLoS …, 2012 - journals.plos.org
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …

[HTML][HTML] Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes

JM Escola, MJ Kleijmeer, W Stoorvogel… - Journal of Biological …, 1998 - ASBMB
Association of major histocompatibility complex (MHC) class II molecules with peptides
occurs in a series of endocytic vacuoles, termed MHC class II-enriched compartments (MIICs). …

Endothelial cells require miR-214 to secrete exosomes that suppress senescence and induce angiogenesis in human and mouse endothelial cells

BWM van Balkom, OG De Jong, M Smits… - Blood, The Journal …, 2013 - ashpublications.org
Signaling between endothelial cells, endothelial progenitor cells, and stromal cells is crucial
for the establishment and maintenance of vascular integrity and involves exosomes, among …

Exosome: from internal vesicle of the multivesicular body to intercellular signaling device

K Denzer, MJ Kleijmeer, HFG Heijnen… - Journal of cell …, 2000 - journals.biologists.com
Exosomes are small membrane vesicles that are secreted by a multitude of cell types as a
consequence of fusion of multivesicular late endosomes/lysosomes with the plasma …