Nanomedicine formulations aim to improve the biodistribution and the target site
accumulation of systemically administered (chemo)therapeutic agents. Many different types of …

Despite continuous improvements in delivery systems, the development of methods for
efficient and specific delivery of targeted therapeutic agents still remains an issue in biological …

Many different systems and strategies have been evaluated for drug targeting to tumors over
the years. Routinely used systems include liposomes, polymers, micelles, nanoparticles …

One possibility for bringing drugs to their specific targets is to use the drug-laden liposomes
that have been made target-specific by the attachment of appropriate proteins. Such ‘directed…

Sterically stabilized liposomes are considered promising carriers of therapeutic agents because
they can facilitate controlled release of the drugs, thereby reducing drug-related toxicity …

The present paper reports on the results of a systematic study on liposome variables
potentially affecting lymphatic disposition and biodistribution of liposomes after sc injection. …

Potent sequence selective gene inhibition by siRNA ‘targeted’ therapeutics promises the
ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake, …

MRI detectable and targeted quantum dots were developed. To that aim, quantum dots were
coated with paramagnetic and pegylated lipids, which resulted in a relaxivity, r 1 , of nearly …

Angiogenesis is a key process in the growth and metastasis of a tumor. Disrupting this
process is considered a promising treatment strategy. Therefore, a drug delivery system …

Previously, we showed that long-circulating polyethylene glycol (PEG)-liposomes are cleared
rapidly from the circulation when injected repeatedly in the same animal. In this article, we …