The human insulin-like growth factors (IGFs) are important regulators of growth, which exert
their functions via endocrine, paracrine and autocrine mechanisms of action. Structural …

… Jansen M, van Schaik FMA, van Tol H, Van den Brande JL, Sussenbach JS. Nucleotide
sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an …

ABSTRACT: Translational regulation of mRNA is an important step in the control of gene
expression. In a general way, the efficiency of the translational apparatus can be influenced …

Somatomedins (SM) or insulin-like growth factors (IGF) constitute a heterogeneous group of
peptides 1 with important growth-promoting effects in vitro 2,3 as well as in vivo 4,5 . Amino …

Addition of insulin-like growth factor I (IGF-I) to quiescent breast tumor-derived MCF-7 cells
causes stimulation of cyclin D1 synthesis, hyperphosphorylation of the retinoblastoma protein …

The insulin‐like growth factors (IGF) play an important role in fetal and postnatal development.
Recently, the nucleotide sequences of the cDNAs encoding IGF‐I and IGF‐II and part of …

Insulin-like growth factor II (IGF-II) is a polypeptide of 67 amino acids which is thought to play
an important role in fetal growth and development. The human IGF-II gene is situated on …

A cDNA probe corresponding to mRNA encoding human somatomedin-C/insulin-like
growth factor I (IGF-I) was used for the chromosomal assignment of the IGF-I gene. Southern-blot …

The human insulin-like growth factor II (IGF-II) gene contains four promoters (P1-P4), which
are expressed in a tissue-specific and development-dependent way. Analysis of IGF-II …

We have isolated 3 cDNA clones encoding human IGF‐II and a variant of IGF‐II. The amino
acid sequence encoded by the IGF‐II cDNA is identical to the sequence previously …