Background The use of cardiopulmonary bypass during coronary artery bypass surgery (CABG)
has been associated with substantial morbidity. The recent introduction of cardiac …

Background The performance of coronary bypass surgery without cardiopulmonary bypass (“off
pump”) may reduce perioperative morbidity and costs, but it is uncertain whether the …

Radiation-induced cardiovascular disease is a well-known complication of radiation exposure.
Over the last few years, planning for deep space missions has increased interest in the …

Objective To gain insight in the underlying mechanism of reduced levels of consciousness
due to hypoactive delirium versus recovery from anesthesia, we studied functional …

In heart failure, cardiac fibrosis is the result of an adverse remodeling process. Collagen is
continuously synthesized in the myocardium in an ongoing attempt of the heart to repair itself. …

Coronary revascularisation plays an important role in the management of patients with ischaemic
heart disease. Its principle builds on restoring antegrade flow thereby relieving angina. …

Cardiac fibroblasts play a key role in chronic heart failure. The conversion from cardiac
fibroblast to myofibroblast as a result of cardiac injury, will lead to excessive matrix deposition …

A fundamental process in the development and progression of heart failure is fibrotic
remodeling, characterized by excessive deposition of extracellular matrix proteins in response to …

In cardiac fibrosis, in response to stress or injury, cardiac fibroblasts deposit excessive
amounts of collagens which contribute to the development of heart failure. The biochemical …

Background— Collaterals limit infarct size, preserve viability, and reduce mortality in patients
with acute myocardial infarction. In patients with stable coronary disease, collaterals are …