Mutations of the multiple endocrine neoplasia type 1 ( MEN1 ) gene lead to loss of function of
its protein product menin. In keeping with its tumor suppressor function in endocrine tissues…

The oncoprotein c-Myc plays an important role in cell proliferation, transformation, inhibition
of differentiation and apoptosis. These functions most likely result from the transcription …

PC4 is a nuclear DNA-binding protein that stimulates activator-dependent class II gene
transcription in vitro. Recent biochemical and X-ray analyses have revealed a unique structure …

Multiple endocrine neoplasia type 1 (MEN1) is caused by inactivating germ line mutations
of the MEN1 tumour suppressor gene. The MEN1 gene product, menin, participates in many …

Objective Epigenetic changes contribute to pancreatic neuroendocrine tumor (PanNET)
development. Hypermethylation of promoter DNA as a cause of tumor suppressor gene …

Previously, we have shown that c-Myc/Max heterodimers, bind cooperatively to the two
adjacent, canonical E-boxes (CACGTG) located in the rat ornithine decarboxylase (ODC) gene. …

Purpose Pancreatic neuroendocrine tumors are a major manifestation of multiple endocrine
neoplasia type 1 (MEN1). This tumor syndrome is caused by germline mutations in MEN1, …

The transforming and oncogenic potential of adenoviruses is localized in the early region 1 (E1),
one of the regions of the viral genome expressed in the early phase of the lytic infection. …

We have cloned the immediate-early serum-reponsive JE gene from the rat in order to study
the regulation of this gene. We show that sequences of the JE promoter region confer serum-…

We have studied promoter opening in assays reconstituted with purified RNA polymerase II
and basal transcription factors. We found that creating a region of heteroduplex DNA around …