Rationale and objectives: Repeated exposure to many drugs of abuse results in a progressive
and enduring enhancement in the motor stimulant effect elicited by a subsequent drug …

Since its conception three decades ago, the idea that the striatum consists of a dorsal
sensorimotor part and a ventral portion processing limbic information has sparked a quest for …

Social play behavior is one of the earliest forms of non-mother-directed social behavior
appearing in ontogeny in mammalian species. During the last century, there has been a lot of …

Compulsive drug use in the face of adverse consequences is a hallmark feature of addiction,
yet there is little preclinical evidence demonstrating the actual progression from casual to …

Like human children, most young mammals devote a significant amount of time and energy
playing together, and social play is fun. Although social play is very pleasurable, it is more …

Impulsivity is a heterogenous phenomenon encompassing several behavioural phenomena
that can be dissociated neuroanatomically as well as pharmacologically. Impulsivity is …

… Baarendse PJJ, Winstanley CA, Vanderschuren LJMJ. Simultaneous blockade of dopamine
and noradrenaline reuptake promotes disadvantageous decision making in a rat gambling …

Abstract Treatment of cocaine addiction is hampered by high rates of relapse even after
prolonged drug abstinence. This relapse to compulsive cocaine use can be triggered by re-…

Through association with the interoceptive effects of drugs of abuse, neutral environmental
stimuli can gain motivational properties themselves, becoming conditioned reinforcers that …

BACKGROUND: Impulsive decision making, apparent as intolerance for reinforcement delay,
is prominent in attention-deficit/hyperactivity disorder. Commonly prescribed for this …