Taxanes belong to a new group of antineoplastic agents with a novel mechanism of action
for a cytotoxic drug. They promote microtubule assembly and stabilize the microtubules. …

Objective To systematically review studies describing the course of functioning in patients
with osteoarthritis (OA) of the hip or knee and identifying potential prognostic factors. Methods …

Objective To determine the long‐term effectiveness (≥6 months after treatment) of exercise
therapy on pain, physical function, and patient global assessment of effectiveness in patients …

Objective The survival benefit of adjuvant radiotherapy and 5-fluorouracil versus observation
alone after surgery was investigated in patients with pancreatic head and periampullary …

The role of IL-6 as a mediator of haemostatic changes during severe inflammation is
controversial. To assess the effect of IL-6 on haemostasis we conducted a controlled cross-over …

Interleukin-6 (IL-6) is one of the major circulating cytokines in catabolic states. To investigate
its endocrinologic and metabolic actions in vivo, we studied eight patients with metastatic …

BACKGROUND The objective of this report is to explore methodologic issues on the basis of
a systematic review of the literature of effectiveness research on palliative cancer care with …

Background This study aims to contribute to the knowledge of the influence of comorbidity in
OA. The objectives of the study were (i) to describe the prevalence of comorbidity and (ii) to …

Objective To determine the effect of patient exercise adherence within the prescribed physical
therapy treatment period and after physical therapy discharge on patient outcomes of pain…

Purpose: To investigate the pharmacokinetics and pharmacodynamics of paclitaxel (P) and
carboplatin (C) in a sequence-finding and dose-escalating study in untreated non-small-cell …