Designing biologically active chemicals and managing their risks requires a holistic
perspective on the chemical-biological interactions that form the basis of selective toxicity. The …

A method of estimating the bioconcentration factor of organic chemicals in fathead minnows
(Pimephales promelas) is described. Water at 25 C was intermittently dosed with the …

Hazard assessments of chemicals have been limited by the availability of test data and the
time needed to evaluate the test data. While available data may be inadequate for the …

The bioaccumulation potential of chemicals is used to indicate when chemicals are likely to
contaminate fish, birds and other wildlife, and humans. Together with knowledge of the …

Narcosis is a nonspecific reversible state of arrested activity of protoplasmic structures caused
by a wide variety of organic chemicals. The vast majority of industrial organic chemicals …

During the last two decades a large number of numerical graph invariants (topological
indices) have been defined and used for correlation analysis in theoretical chemistry, …

Although the literature is replete with QSAR models developed for many toxic effects caused
by reversible chemical interactions, the development of QSARs for the toxic effects of …

The bioconcentration factor (BCF) is a parameter that describes the ability of chemicals to
concentrate in aquatic organisms. Traditionally, it is modeled by the log–log quantitative …

Research with a variety of aquatic species has shown that while polycyclic aromatic
hydrocarbons (PAHs) are generally not acutely toxic in conventional laboratory tests, many are …

The logarithm of the retention time (log RT) of organic chemicals on a permanently bonded (C-18)
reverse-phase high-pressure liquid chromatography system is shown to be linearly …