Background Based on studies published so far, the protective effect of physical activity on
stroke remains controversial. Specifically, there is a lack of insight into the sources of …

We aimed to obtain reliable reference charts for sleep duration, estimate the prevalence of
sleep complaints across the lifespan and identify risk indicators of poor sleep. Studies were …

Cardiovascular diseases (CVD), especially coronary heart disease (CHD), are the most
important causes of death in industrialized countries. Increased concentrations of total plasma …

Background High plasma HDL cholesterol is associated with reduced risk of myocardial
infarction, but whether this association is causal is unclear. Exploiting the fact that genotypes are …

Background Low-risk limits recommended for alcohol consumption vary substantially across
different national guidelines. To define thresholds associated with lowest risk for all-cause …

Objective. —To compare the relationship between serum total cholesterol and long-term
mortality from coronary heart disease (CHD) in different cultures. Design. —Total cholesterol …

Objective: To examine the associations of fatty acid and fish intake with cognitive function.
Methods: Data are from a cross-sectional population-based study among 1,613 subjects …

Importance The prevalence of cardiometabolic multimorbidity is increasing. Objective To
estimate reductions in life expectancy associated with cardiometabolic multimorbidity. Design, …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…