Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …

The classical perception of adipose tissue as a storage place of fatty acids has been replaced
over the last years by the notion that adipose tissue has a central role in lipid and glucose …

Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …

Background Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density
lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on …

Background In a previous study, a single injection of inclisiran, a chemically synthesized
small interfering RNA designed to target PCSK9 messenger RNA, was found to produce …

Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements.
In this Review we discuss trajectories from normal cognition to dementia in people with …

Background: To quantify the association between effects of interventions on carotid intima-media
thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. …

Several cardiovascular risk factors (dyslipidaemia, hypertension, glucose intolerance,
hypercoagulability, obesity, hyperinsulinaemia and low-grade inflammation) cluster in the insulin …

Aims The metabolic syndrome is associated with an increased risk of cardiovascular
disease in patients without a cardiovascular history. We investigated whether the metabolic …

Introduction Whether long-term treatment with the twice-yearly, siRNA therapeutic inclisiran,
which reduces hepatic production of proprotein convertase subtilisin/kexin type 9 (PCSK9), …