2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: Developed by the Task Force for cardiovascular disease prevention in clinical practice …
FLJ Visseren, F Mach, YM Smulders… - European heart …, 2021 - academic.oup.com
Atherosclerotic cardiovascular (CV) disease (ASCVD) incidence and mortality rates are
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …
declining in many countries in Europe, but it is still a major cause of morbidity and mortality …
Adipose tissue dysfunction in obesity, diabetes, and vascular diseases
GR Hajer, TW Van Haeften… - European heart …, 2008 - academic.oup.com
The classical perception of adipose tissue as a storage place of fatty acids has been replaced
over the last years by the notion that adipose tissue has a central role in lipid and glucose …
over the last years by the notion that adipose tissue has a central role in lipid and glucose …
Obesity and cancer: the role of dysfunctional adipose tissue
RCM Van Kruijsdijk, E Van Der Wall… - … , biomarkers & prevention, 2009 - AACR
Overweight and obesity are health problems of epidemic proportions, increasing the risk not
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …
only of cardiovascular disease and type 2 diabetes mellitus but also of various types of …
Simvastatin with or without ezetimibe in familial hypercholesterolemia
JJP Kastelein, F Akdim, ESG Stroes… - … England Journal of …, 2008 - Mass Medical Soc
Background Ezetimibe, a cholesterol-absorption inhibitor, reduces levels of low-density
lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on …
lipoprotein (LDL) cholesterol when added to statin treatment. However, the effect of ezetimibe on …
Inclisiran in patients at high cardiovascular risk with elevated LDL cholesterol
Background In a previous study, a single injection of inclisiran, a chemically synthesized
small interfering RNA designed to target PCSK9 messenger RNA, was found to produce …
small interfering RNA designed to target PCSK9 messenger RNA, was found to produce …
Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
GJ Biessels, MWJ Strachan, FLJ Visseren… - The lancet Diabetes & …, 2014 - thelancet.com
Type 2 diabetes is associated with dementia, and also with more slight cognitive decrements.
In this Review we discuss trajectories from normal cognition to dementia in people with …
In this Review we discuss trajectories from normal cognition to dementia in people with …
Long-term efficacy and safety of inclisiran in patients with high cardiovascular risk and elevated LDL cholesterol (ORION-3): results from the 4-year open-label …
KK Ray, RPT Troquay, FLJ Visseren… - The Lancet Diabetes & …, 2023 - thelancet.com
Introduction Whether long-term treatment with the twice-yearly, siRNA therapeutic inclisiran,
which reduces hepatic production of proprotein convertase subtilisin/kexin type 9 (PCSK9), …
which reduces hepatic production of proprotein convertase subtilisin/kexin type 9 (PCSK9), …
Metabolic and additional vascular effects of thiazolidinediones
FMAC Martens, FLJ Visseren, J Lemay, EJP de Koning… - Drugs, 2002 - Springer
Several cardiovascular risk factors (dyslipidaemia, hypertension, glucose intolerance,
hypercoagulability, obesity, hyperinsulinaemia and low-grade inflammation) cluster in the insulin …
hypercoagulability, obesity, hyperinsulinaemia and low-grade inflammation) cluster in the insulin …
The metabolic syndrome is associated with advanced vascular damage in patients with coronary heart disease, stroke, peripheral arterial disease or abdominal aortic …
JK Olijhoek, Y van der Graaf, JD Banga… - European heart …, 2004 - academic.oup.com
Aims The metabolic syndrome is associated with an increased risk of cardiovascular
disease in patients without a cardiovascular history. We investigated whether the metabolic …
disease in patients without a cardiovascular history. We investigated whether the metabolic …
Role of adipose tissue in haemostasis, coagulation and fibrinolysis
DR Faber, PHG De Groot, FLJ Visseren - Obesity reviews, 2009 - Wiley Online Library
Obesity is associated with an increased incidence of insulin resistance (IR), type 2 diabetes
mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could …
mellitus and cardiovascular diseases. The increased risk for cardiovascular diseases could …