The suffering of patients with incurable cancer is determined to a large degree by the
presence and intensity of the symptoms of their disease. Knowledge of symptom prevalence is …

Large numbers of inhibitors for polo-like kinases and aurora kinases are currently being
evaluated as anticancer drugs. Interest in these drugs is fuelled by the idea that these kinases …

The current COVID-19 pandemic challenges oncologists to profoundly re-organize
oncological care in order to dramatically reduce hospital visits and admissions and therapy-induced …

Background Fluoropyrimidine-based chemotherapy plus the anti–vascular endothelial
growth factor (VEGF) antibody bevacizumab is standard first-line treatment for metastatic …

PD-1 plus CTLA-4 blockade is highly effective in advanced-stage, mismatch repair (MMR)-deficient
(dMMR) colorectal cancers, yet not in MMR-proficient (pMMR) tumors. We postulated …

Breast cancer (BC) comprises multiple distinct subtypes that differ genetically, pathologically,
and clinically. Here, we describe a robust protocol for long-term culturing of human …

The AACR Project GENIE is an international data-sharing consortium focused on generating
an evidence base for precision cancer medicine by integrating clinical-grade cancer …

Background: In previous animal studies, interleukin 12 (IL 12) was shown to inhibit the growth
of a wide spectrum of tumors in vivo but to have no direct effect on tumor cells in vitro. Also, …

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Cancer immunotherapies have shown substantial clinical activity for a subset of patients
with epithelial cancers. Still, technological platforms to study cancer T-cell interactions for …