1. Introduction(electrical heterogeneity with nonuniform repolarization and refractoriness)
for the initiation and perpetuation of Afterdepolarizations are oscillations of the transmem- …

Torsades de pointes (TdP) is a malignant polymorphic ventricular tachyarrhythmia that can
be caused by drugs that induce electrophysiological changes. Although the number of drugs …

It is known that myocardial ischaemia and infarction leads to severe metabolic and
electrophysiological changes that induce silent or symptomatic life-threatening arrhythmias. Sudden …

Introduction. Sudden arrhythmogenic cardiac death is a major cause of mortality in patients
with congestive heart failure due to adverse electrical remodelling. To establish whether …

Background— Identification of patients at risk for drug-induced torsades de pointes arrhythmia
(TdP) is difficult. Increased temporal lability of repolarization has been suggested as …

Background—Chronic, complete AV block (CAVB) in the dog leads to ventricular hypertrophy,
which has been described as an independent risk factor for arrhythmias. In this model, we …

Background—Ventricular arrhythmias are a major cause of sudden death in patients with heart
failure and hypertrophy. The dog with chronic complete atrioventricular block (CAVB) has …

Background— In large mammals and humans, the contribution of I Ks to ventricular
repolarization is still incompletely understood. Methods and Results— In vivo and cellular …

Background—Acquired QT prolongation enhances the susceptibility to torsades de pointes (TdP).
Clinical and experimental studies indicate ventricular action potential prolongation, …

Deletion of amino-acid residues 1505–1507 (KPQ) in the cardiac SCN5A Na + channel
causes autosomal dominant prolongation of the electrocardiographic QT interval (long-QT …