Overcoming the blood–brain tumor barrier for effective glioblastoma treatment
O Van Tellingen, B Yetkin-Arik, MC De Gooijer… - Drug Resistance …, 2015 - Elsevier
Gliomas are the most common primary brain tumors. Particularly in adult patients, the vast
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …
majority of gliomas belongs to the heterogeneous group of diffuse gliomas, ie. glial tumors …
The immunosuppressive tumour network: myeloid‐derived suppressor cells, regulatory T cells and natural killer T cells
D Lindau, P Gielen, M Kroesen, P Wesseling… - …, 2013 - Wiley Online Library
Myeloid‐derived suppressor cells ( MDSC ) and regulatory T (Treg) cells are major components
of the immune suppressive tumour microenvironment ( TME ). Both cell types expand …
of the immune suppressive tumour microenvironment ( TME ). Both cell types expand …
The 2021 WHO classification of tumors of the central nervous system: a summary
The fifth edition of the WHO Classification of Tumors of the Central Nervous System (CNS),
published in 2021, is the sixth version of the international standard for the classification of …
published in 2021, is the sixth version of the international standard for the classification of …
DNA methylation-based classification of central nervous system tumours
Accurate pathological diagnosis is crucial for optimal management of patients with cancer.
For the approximately 100 known tumour types of the central nervous system, standardization …
For the approximately 100 known tumour types of the central nervous system, standardization …
Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year …
Background In 2004, a randomised phase III trial by the European Organisation for Research
and Treatment of Cancer (EORTC) and National Cancer Institute of Canada Clinical Trials …
and Treatment of Cancer (EORTC) and National Cancer Institute of Canada Clinical Trials …
[PDF][PDF] New brain tumor entities emerge from molecular classification of CNS-PNETs
Primitive neuroectodermal tumors of the central nervous system (CNS-PNETs) are highly
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …
aggressive, poorly differentiated embryonal tumors occurring predominantly in young children …
I nternational S ociety of N europathology‐H aarlem C onsensus G uidelines for N ervous S ystem T umor C lassification and G rading
Major discoveries in the biology of nervous system tumors have raised the question of how
non‐histological data such as molecular information can be incorporated into the next W orld …
non‐histological data such as molecular information can be incorporated into the next W orld …
[HTML][HTML] RNA-Seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic
and local responses to tumor growth, thereby altering their RNA profile. We determined the …
and local responses to tumor growth, thereby altering their RNA profile. We determined the …
[PDF][PDF] Glioma progression is shaped by genetic evolution and microenvironment interactions
The factors driving therapy resistance in diffuse glioma remain poorly understood. To
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
identify treatment-associated cellular and genetic changes, we analyzed RNA and/or DNA …
[HTML][HTML] Sarcoma classification by DNA methylation profiling
C Koelsche, D Schrimpf, D Stichel, M Sill… - Nature …, 2021 - nature.com
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and
children. They represent a morphologically heterogeneous class of tumours and some entities …
children. They represent a morphologically heterogeneous class of tumours and some entities …