Purpose Breast cancer is the most common malignancy among young women of reproductive
age. Adjuvant treatment with tamoxifen reduces the risk of recurrence in hormone-…

Background A geriatric assessment (GA) is increasingly used to help guide treatment decisions
in older patients with cancer. However, there is no consensus regarding which domains …

Anti-VEGF (vascular endothelial growth factor) therapy with the monoclonal antibody
bevacizumab can cause gastrointestinal (GI) perforations. In recent years it became apparent that …

The development of guidelines recommendations is one of the core activities of the European
Society for Medical Oncology (ESMO) and European Society of Gynaecologial Oncology (…

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Ovarian cancer (OC) is a heterogeneous disease usually diagnosed at a late stage. Experimental
in vitro models that faithfully capture the hallmarks and tumor heterogeneity of OC are …

Purpose We aimed to determine the prognosis of patients with breast cancer diagnosed
during pregnancy (BCP). Patients and Methods In this cohort study, a multicentric registry of …

Purpose: Ribociclib (an oral, highly specific cyclin-dependent kinase 4/6 inhibitor) inhibits
tumor growth in preclinical models with intact retinoblastoma protein (Rb + ). This first-in-…

There remains an unmet need for preclinical models to enable personalized therapy for
ovarian cancer (OC) patients. Here we evaluate the capacity of patient-derived organoids (PDOs…

PURPOSE: To evaluate dosimetric parameters and clinical outcome for cervical cancer
patients treated with chemo-radiation and MR-image guided adaptive brachytherapy (MR-IGABT…