Mechanisms of Host Defense against Infection with Streptococcus pneumoniae

GAW Bruyn, BJM Zegers… - Clinical infectious …, 1992 - academic.oup.com
Various aspects of the host's response to infection by Streptococcus pneumoniae are reviewed.
First, the structure of the bacterium is described, with a focus on those elements that are …

Infant B cell responses to polysaccharide determinants

GT Rijkers, EAM Sanders, MA Breukels, BJM Zegers - Vaccine, 1998 - Elsevier
Newborns and infants up to the age of 1.5–2 years of age are unable to produce antibodies
to bacterial capsular polysaccharides. As a consequence, children up to the age of 2 years …

CD40lbase: a database of CD40L gene mutations causing X-linked hyper-IgM syndrome

LD Notarangelo, MC Peitsch, TG Abrahamsen… - Immunology Today, 1996 - cell.com
X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the
gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has …

Serum immunoglobulin levels in healthy children and adults

JW Stoop, BJM Zegers, PC Sander… - Clinical and …, 1969 - ncbi.nlm.nih.gov
Serum levels of IgM, IgG and IgA were determined in 270 healthy children, 4–12 years old,
and in thirty healthy adults by the radial immunodiffusion method of Mancini. There were nine …

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis

ER De Graeff-Meeder, GT Rijkers, W Kuis, BJM Zegers… - The Lancet, 1991 - Elsevier
A postulated mechanism for autoimmune disorders is that the immunoreactivity develops
against bacterial antigens which show a high degree of sequence homology with mammalian …

Fcã receptor Iia (Cd32) heterogeneity in patients with recurrent bacterial respiratory tract infections

LAM Sanders, JGJ van de Winkel… - Journal of Infectious …, 1994 - academic.oup.com
… Rijkers GT, Sanders EAM, Zegers BJM. Anti-capsular polysaccharide antibody deficiency …
Zegers BJM, van der Giessen M, Reerink-Brongers EE, Stoop JW. The serum IgG subclass …

Purine nucleoside phosphorylase deficiency associated with selective cellular immunodeficiency

JW Stoop, BJM Zegers, GFM Hendrickx… - … England Journal of …, 1977 - Mass Medical Soc
We studied a 15-month-old girl who had normal T-cell and B-cell immunity at birth, after
which a gradual decrease in T-cell immunity developed. This selective cellular …

Defective antipneumococcal polysaccharide antibody response in children with recurrent respiratory tract infections

LAM Sanders, GT Rijkers, W Kuis… - Journal of allergy and …, 1993 - Elsevier
Background: Recurrent pyogenic infections are known to occur in patients with an impaired
response to polysaccharide antigens. We investigated the occurrence of deficient responses …

Autoreactivity to human heat‐shock protein 60 predicts disease remission in oligoarticular juvenile rheumatoid arthritis

ABJ Prakken, W Van Eden, GT Rijkers… - Arthritis & …, 1996 - Wiley Online Library
Objective. To determine whether T lymphocyte reactivity to endogenous human hsp60 plays
a regulatory role in the course of oligoarticular juvenile rheumatoid arthritis (JRA). Methods. …

Lysogenic Conversion of Staphylococci to Loss of β-Toxin

KC Winkler, J De Waart, C Grootsen… - …, 1965 - microbiologyresearch.org
Staphylococci may produce β-toxin and staphylokinase (fibrinolysin). In clinical material there
is a preponderance of strains which are β-toxin negative and kinase positive (β – K + ), but …