Various aspects of the host's response to infection by Streptococcus pneumoniae are reviewed.
First, the structure of the bacterium is described, with a focus on those elements that are …

Newborns and infants up to the age of 1.5–2 years of age are unable to produce antibodies
to bacterial capsular polysaccharides. As a consequence, children up to the age of 2 years …

X-linked hyper-IgM syndrome (X-HIM) is an immunodeficiency caused by mutations in the
gene encoding the CD40 ligand (CD40L). A database (CD40Lbase) of CD40L mutations has …

Serum levels of IgM, IgG and IgA were determined in 270 healthy children, 4–12 years old,
and in thirty healthy adults by the radial immunodiffusion method of Mancini. There were nine …

… Rijkers GT, Sanders EAM, Zegers BJM. Anti-capsular polysaccharide antibody deficiency …
Zegers BJM, van der Giessen M, Reerink-Brongers EE, Stoop JW. The serum IgG subclass …

A postulated mechanism for autoimmune disorders is that the immunoreactivity develops
against bacterial antigens which show a high degree of sequence homology with mammalian …

We studied a 15-month-old girl who had normal T-cell and B-cell immunity at birth, after
which a gradual decrease in T-cell immunity developed. This selective cellular …

Background: Recurrent pyogenic infections are known to occur in patients with an impaired
response to polysaccharide antigens. We investigated the occurrence of deficient responses …

Objective. To determine whether T lymphocyte reactivity to endogenous human hsp60 plays
a regulatory role in the course of oligoarticular juvenile rheumatoid arthritis (JRA). Methods. …

… Rijkers GT, Sanders LAM, Zegers BJM: Anti-capsular polysaccharide antibody deficiency
states. Iminunodef 5:1-21, 1993 24. Hidalgo H, Moore C, Leiva L, Sorensen RU: …