Eph receptors and their ephrin ligands are important guidance molecules during neurological
and vascular development. In recent years, it has become clear that the Eph protein family …

Results Compared with healthy controls (1.82±0.16 µm), ESRD patients had a larger perfused
boundary region (+ 0.23; 95% confidence interval, 0.46 to< 0.01; P< 0.05), which signifies …

Plasminogen activator inhibitor 1 (PAI-1), an essential regulatory protein of the fibrinolytic
system, harbors interaction sites for plasminogen activators (tissue-type [t-PA] and urokinase-…

The gut microbiota has emerged as an important modulator of cardiovascular and renal
homeostasis. The composition of gut microbiota in patients suffering from chronic kidney disease …

In normal physiology, endothelial cells (ECs) form a vital barrier between the blood and
underlying tissue controlling leukocyte diapedesis and vascular inflammation. Emerging data …

Objective: Besides hyperlipidemia, inflammation is an important determinant in the initiation
and the progression of atherosclerosis. As Neuroimmune Guidance Cues (NGCs) are …

Vitronectin (VN) is an obligatory cofactor for the inhibition of thrombin by plasminogen
activator inhibitor 1 (PAI-1). It accelerates the rate of association between thrombin and PAI-1 …

Atherosclerosis is the underlying pathology in a major part of cardiovascular disease, the
leading cause of mortality in developed countries. The infiltration of monocytes into the vessel …

In the pathophysiologic setting of acute and chronic kidney injury, the excessive activation
and recruitment of blood-borne monocytes prompts their differentiation into inflammatory …

The prevalence of end-stage kidney disease (ESKD) is rapidly increasing and mostly
occurring in patients aged 65 years or older. The main cause of death in these patients is …