| Antibody phage display technology and its applications HR Hoogenboom, AP de Bruıne, SE Hufton, RM Hoet, JW Arends, ... Immunotechnology 4 (1), 1-20, 1998 | 900 | 1998 |
| A large non-immunized human Fab fragment phage library that permits rapid isolation and kinetic analysis of high affinity antibodies HJ de Haard, N van Neer, A Reurs, SE Hufton, RC Roovers, P Henderikx, ... Journal of Biological Chemistry 274 (26), 18218-18230, 1999 | 738 | 1999 |
| Efficient inhibition of EGFR signalling and of tumour growth by antagonistic anti-EGFR Nanobodies RC Roovers, T Laeremans, L Huang, S De Taeye, AJ Verkleij, H Revets, ... Cancer immunology, immunotherapy 56, 303-317, 2007 | 447 | 2007 |
| Design and application of diabodies, triabodies and tetrabodies for cancer targeting A Todorovska, RC Roovers, O Dolezal, AA Kortt, HR Hoogenboom, ... Journal of immunological methods 248 (1-2), 47-66, 2001 | 441 | 2001 |
| Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor DMW Zaiss, J Van Loosdregt, A Gorlani, CPJ Bekker, A Gröne, M Sibilia, ... Immunity 38 (2), 275-284, 2013 | 401 | 2013 |
| A biparatopic anti‐EGFR nanobody efficiently inhibits solid tumour growth RC Roovers, MJWD Vosjan, T Laeremans, R el Khoulati, RCG de Bruin, ... International journal of cancer 129 (8), 2013-2024, 2011 | 285 | 2011 |
| ErbB1 dimerization is promoted by domain co-confinement and stabilized by ligand binding ST Low-Nam, KA Lidke, PJ Cutler, RC Roovers, ... Nature structural & molecular biology 18 (11), 1244-1249, 2011 | 283 | 2011 |
| Regulation of Tiam1–rac signalling AE Mertens, RC Roovers, JG Collard FEBS letters 546 (1), 11-16, 2003 | 268 | 2003 |
| Structural evaluation of EGFR inhibition mechanisms for nanobodies/VHH domains KR Schmitz, A Bagchi, RC Roovers, PMPB en Henegouwen, ... Structure 21 (7), 1214-1224, 2013 | 219 | 2013 |
| Rapid visualization of human tumor xenografts through optical imaging with a near-infrared fluorescent anti–epidermal growth factor receptor nanobody S Oliveira, GAMS Van Dongen, MS Walsum, RC Roovers, JC Stam, ... Molecular imaging 11 (1), 7290.2011. 00025, 2012 | 219 | 2012 |
| Crosstalk between epidermal growth factor receptor-and insulin-like growth factor-1 receptor signaling: implications for cancer therapy S Oliveira, RM Schiffelers, G Storm, PMP Henegouwen, RC Roovers Current cancer drug targets 9 (6), 748-760, 2009 | 217 | 2009 |
| Human anti-CD30 recombinant antibodies by guided phage antibody selection using cell panning A Klimka, B Matthey, RC Roovers, S Barth, JW Arends, A Engert, ... British journal of cancer 83 (2), 252-260, 2000 | 172 | 2000 |
| Downregulation of EGFR by a novel multivalent nanobody-liposome platform S Oliveira, RM Schiffelers, J van der Veeken, R van der Meel, ... Journal of Controlled Release 145 (2), 165-175, 2010 | 167 | 2010 |
| EGF induces coalescence of different lipid rafts EG Hofman, MO Ruonala, AN Bader, D van den Heuvel, J Voortman, ... Journal of cell science 121 (15), 2519-2528, 2008 | 162 | 2008 |
| Guided selection of a pan carcinoma specific antibody reveals similar binding characteristics yet structural divergence between the original murine antibody and its human … SHW Beiboer, A Reurs, RC Roovers, JW Arends, NR Whitelegg, AR Rees, ... Journal of Molecular Biology 296 (3), 833-849, 2000 | 132 | 2000 |
| Facile labelling of an anti-epidermal growth factor receptor Nanobody with 68Ga via a novel bifunctional desferal chelate for immuno-PET MJWD Vosjan, LR Perk, RC Roovers, GWM Visser, M Stigter-van Walsum, ... European journal of nuclear medicine and molecular imaging 38, 753-763, 2011 | 123 | 2011 |
| Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment R Van Der Meel, S Oliveira, I Altintas, R Haselberg, J Van Der Veeken, ... Journal of controlled release 159 (2), 281-289, 2012 | 110 | 2012 |
| Therapeutic stem cells expressing variants of EGFR-specific nanobodies have antitumor effects JAJM van de Water, T Bagci-Onder, AS Agarwal, H Wakimoto, ... Proceedings of the National Academy of Sciences 109 (41), 16642-16647, 2012 | 104 | 2012 |
| Nanobodies in therapeutic applications. RC Roovers, GA Van Dongen, PM Van Bergen En Henegouwen Current opinion in molecular therapeutics 9 (4), 327-335, 2007 | 102 | 2007 |
| An anti-CD30 single-chain Fv selected by phage display and fused to Pseudomonas exotoxin A (Ki-4 (scFv)-ETA’) is a potent immunotoxin against a Hodgkin-derived cell line A Klimka, S Barth, B Matthey, RC Roovers, H Lemke, H Hansen, ... British journal of cancer 80 (8), 1214-1222, 1999 | 102 | 1999 |
