Recent advances in the chemistry of ynamines and ynamides CA Zificsak, JA Mulder, RP Hsung, C Rameshkumar, LL Wei Tetrahedron 57 (36), 7575-7606, 2001 | 327 | 2001 |
Efficient preparations of novel ynamides and allenamides LL Wei, JA Mulder, H Xiong, CA Zificsak, CJ Douglas, RP Hsung Tetrahedron 57 (3), 459-466, 2001 | 188 | 2001 |
Current methods for the synthesis of 2-substituted azoles CA Zificsak, DJ Hlasta Tetrahedron 60 (41), 8991-9016, 2004 | 187 | 2004 |
Highly stereoselective synthesis of novel α-haloenamides via a mild and efficient hydrohalogenation of ynamides JA Mulder, KCM Kurtz, RP Hsung, H Coverdale, MO Frederick, L Shen, ... Organic Letters 5 (9), 1547-1550, 2003 | 144 | 2003 |
The First Stereoselective Ficini− Claisen Rearrangement Using Chiral Ynamides JA Mulder, RP Hsung, MO Frederick, MR Tracey, CA Zificsak Organic Letters 4 (8), 1383-1386, 2002 | 120 | 2002 |
Intramolecular formal aza-[3+ 3] cycloaddition approach to indoloquinolizidine alkaloids. A stereoselective total synthesis of (±)-tangutorine S Luo, CA Zificsak, RP Hsung Organic Letters 5 (24), 4709-4712, 2003 | 101 | 2003 |
Lewis Acid Promoted Hetero [2+ 2] Cycloaddition Reactions of Aldehydes with 10-Propynyl-9 (10 H)-acridone. A Highly Stereoselective Synthesis of Acrylic Acid Derivatives and 1 … RP Hsung, CA Zificsak, LL Wei, CJ Douglas, H Xiong, JA Mulder Organic Letters 1 (8), 1237-1240, 1999 | 99 | 1999 |
A formal [3+ 3] cycloaddition reaction. improved reactivity using α, β-unsaturated iminium salts and evidence for reversibility of 6π-electron electrocyclic ring closure of 1 … HC Shen, J Wang, KP Cole, MJ McLaughlin, CD Morgan, CJ Douglas, ... The Journal of Organic Chemistry 68 (5), 1729-1735, 2003 | 85 | 2003 |
Fused bicyclic derivatives of 2, 4-diaminopyrimidine as ALK and c-Met inhibitors G Ahmed, HJ Breslin, J Burke, MA Curry, JL Diebold, B Dorsey, BJ Dugan, ... US Patent 8,148,391, 2012 | 67 | 2012 |
A rare acid-promoted elimination of O-methyl oximes: A practical synthesis of 3-cyano-4-benzopyrones RP Hsung, CA Zificsak, LL Wei, LR Zehnder, F Park, M Kim, TTT Tran Journal of organic chemistry 64, 8736-8740, 1999 | 57 | 1999 |
Combined inhibition of atypical PKC and histone deacetylase 1 is cooperative in basal cell carcinoma treatment AN Mirza, MA Fry, NM Urman, SX Atwood, J Roffey, GR Ott, B Chen, ... JCI insight 2 (21), 2017 | 52 | 2017 |
Total syntheses of enantiomerically enriched R-(+)-and S-(−)-deplancheine N Sydorenko, CA Zificsak, AI Gerasyuto, RP Hsung Organic & Biomolecular Chemistry 3 (11), 2140-2144, 2005 | 38 | 2005 |
Strategies to Mitigate the Bioactivation of 2-Anilino-7-Aryl-Pyrrolo[2,1-f][1,2,4]triazines: Identification of Orally Bioavailable, Efficacious ALK Inhibitors EF Mesaros, TV Thieu, GJ Wells, CA Zificsak, JC Wagner, HJ Breslin, ... Journal of Medicinal Chemistry 55 (1), 115-125, 2012 | 37 | 2012 |
Synthesis and structure–activity relationships of 1, 2, 3, 4-tetrahydropyrido [2, 3-b] pyrazines as potent and selective inhibitors of the anaplastic lymphoma kinase KL Milkiewicz, LR Weinberg, MS Albom, TS Angeles, M Cheng, AK Ghose, ... Bioorganic & medicinal chemistry 18 (12), 4351-4362, 2010 | 35 | 2010 |
Stereoselective trans- and cis-Dihydroxylations of 2H-Pyranyl and Dihydropyridinyl Heterocycles Synthesized from Formal [3 + 3]-Cycloaddition Reactions of α,β … LR Zehnder, LL Wei, RP Hsung, KP Cole, MJ McLaughlin, HC Shen, ... Organic Letters 3 (14), 2141-2144, 2001 | 35 | 2001 |
Pyridopyrazines and derivatives thereof as ALK and c-Met inhibitors BD Dorsey, KL Milkiewicz, DA Pippin, JP Theroff, T Underiner, ... US Patent 7,601,716, 2009 | 31 | 2009 |
Design, synthesis, and biological evaluation of sulfonyl acrylonitriles as novel inhibitors of cancer metastasis and spread Y Shen, CA Zificsak, JE Shea, X Lao, O Bollt, X Li, JG Lisko, JP Theroff, ... Journal of Medicinal Chemistry 58 (3), 1140-1158, 2015 | 30 | 2015 |
A stereoselective intramolecular halo-etherification of chiral enamides in the synthesis of halogenated cyclic ethers C Ko, RP Hsung, ZF Al-Rashid, JB Feltenberger, T Lu, JH Yang, Y Wei, ... Organic Letters 9 (22), 4459-4462, 2007 | 30 | 2007 |
Fused bicyclic derivatives of 2, 4-diaminopyrimidine as c-Met inhibitors LR Weinberg, MS Albom, TS Angeles, J Husten, JG Lisko, RJ McHugh, ... Bioorganic & medicinal chemistry letters 21 (1), 164-167, 2011 | 29 | 2011 |
Synthesis of dihydroxanthone derivatives and evaluation of their inhibitory activity against acetylcholinesterase: Unique structural analogs of tacrine based on the BCD-ring of … SJ Degen, KL Mueller, HC Shen, JA Mulder, GM Golding, L Wei, ... Bioorganic & medicinal chemistry letters 9 (7), 973-978, 1999 | 29 | 1999 |