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Fangrui Wu
Fangrui Wu
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The Pictet–Spengler reaction in nature and in organic chemistry
J Stöckigt, AP Antonchick, F Wu, H Waldmann
Angewandte Chemie International Edition 50 (37), 8538-8564, 2011
6892011
Targeting histone methylation for cancer therapy: enzymes, inhibitors, biological activity and perspectives
Y Song, F Wu, J Wu
Journal of hematology & oncology 9, 1-21, 2016
1472016
Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia
Z Feng, Y Yao, C Zhou, F Chen, F Wu, L Wei, W Liu, S Dong, M Redell, ...
Journal of hematology & oncology 9, 1-13, 2016
1122016
Discovery, X-ray crystallography and antiviral activity of allosteric inhibitors of flavivirus NS2B-NS3 protease
Y Yao, T Huo, YL Lin, S Nie, F Wu, Y Hua, J Wu, AR Kneubehl, MB Vogt, ...
Journal of the American Chemical Society 141 (17), 6832-6836, 2019
982019
Inhibition of cancer-associated mutant isocitrate dehydrogenases by 2-thiohydantoin compounds
F Wu, H Jiang, B Zheng, M Kogiso, Y Yao, C Zhou, XN Li, Y Song
Journal of medicinal chemistry 58 (17), 6899-6908, 2015
902015
3-(Piperidin-4-ylmethoxy) pyridine containing compounds are potent inhibitors of lysine specific demethylase 1
F Wu, C Zhou, Y Yao, L Wei, Z Feng, L Deng, Y Song
Journal of medicinal chemistry 59 (1), 253-263, 2016
882016
Die Pictet‐Spengler‐Reaktion in der Natur und der organischen Chemie
J Stöckigt, AP Antonchick, F Wu, H Waldmann
Angewandte Chemie 123 (37), 8692-8719, 2011
682011
Scaffold tailoring by a newly detected Pictet–Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework
F Wu, H Zhu, L Sun, C Rajendran, M Wang, X Ren, S Panjikar, ...
Journal of the American Chemical Society 134 (3), 1498-1500, 2012
622012
Acetylation of histone H3K27 signals the transcriptional elongation for estrogen receptor alpha
Y Gao, L Chen, Y Han, F Wu, WS Yang, Z Zhang, T Huo, Y Zhu, C Yu, ...
Communications Biology 3 (1), 165, 2020
312020
Synthesis, Structure–Activity Relationships, and Antiviral Activity of Allosteric Inhibitors of Flavivirus NS2B–NS3 Protease
S Nie, Y Yao, F Wu, X Wu, J Zhao, Y Hua, J Wu, T Huo, YL Lin, ...
Journal of medicinal chemistry 64 (5), 2777-2800, 2021
262021
Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease
S Nie, J Zhao, X Wu, Y Yao, F Wu, YL Lin, X Li, AR Kneubehl, MB Vogt, ...
European journal of medicinal chemistry 225, 113767, 2021
212021
Discovery, structure–activity relationship, and biological activity of histone-competitive inhibitors of histone acetyltransferases P300/CBP
F Wu, Y Hua, S Kaochar, S Nie, YL Lin, Y Yao, J Wu, X Wu, X Fu, R Schiff, ...
Journal of medicinal chemistry 63 (9), 4716-4731, 2020
202020
Using strictosidine synthase to prepare novel alkaloids
H Zhu, P Kercmar, F Wu, C Rajendran, L Sun, M Wang, J Stockigt
Current Medicinal Chemistry 22 (15), 1880-1888, 2015
202015
Sarpagan-Ajmalan-Type Indoles: Biosynthesis, structural biology, and chemo-enzymatic significance
F Wu, P Kerčmar, C Zhang, J Stöckigt
The Alkaloids: Chemistry and Biology 76, 1-61, 2016
162016
Small-molecule inhibitor of AF9/ENL-DOT1L/AF4/AFF4 interactions suppresses malignant gene expression and tumor growth
F Wu, S Nie, Y Yao, T Huo, X Li, X Wu, J Zhao, YL Lin, Y Zhang, Q Mo, ...
Theranostics 11 (17), 8172, 2021
152021
A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth
X Li, Y Yao, F Wu, Y Song
Journal of Hematology & Oncology 15 (1), 41, 2022
132022
Glucocorticoids inhibit oncogenic RUNX1-ETO in acute myeloid leukemia with chromosome translocation t (8; 21)
L Lu, Y Wen, Y Yao, F Chen, G Wang, F Wu, J Wu, P Narayanan, ...
Theranostics 8 (8), 2189, 2018
122018
Structure activity relationship and modeling studies of inhibitors of lysine specific demethylase 1
C Zhou, F Wu, L Lu, L Wei, E Pai, Y Yao, Y Song
PLoS One 12 (2), e0170301, 2017
122017
Determination of 1-deoxynojirimycin in Morus alba L. leaves using reversed-phase high performance liquid chromatography fluorescence detection with pre-column derivatization
H Xie, F Wu, Y Yang, J Liu
Se pu= Chinese Journal of Chromatography 26 (5), 634-636, 2008
112008
Structure-activity relationship and antitumor activity of 1, 4-pyrazine-containing inhibitors of histone acetyltransferases P300/CBP
S Nie, F Wu, J Wu, X Li, C Zhou, Y Yao, Y Song
European journal of medicinal chemistry 237, 114407, 2022
72022
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Artikelen 1–20