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Umut H. Toprak
Umut H. Toprak
Translational Development Manager - Oncology, Oxford Nanopore Technologies
Geverifieerd e-mailadres voor nanoporetech.com
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Pan-cancer analysis of whole genomes
Nature 578 (7793), 82-93, 2020
1678*2020
New brain tumor entities emerge from molecular classification of CNS-PNETs
D Sturm, BA Orr, UH Toprak, V Hovestadt, DTW Jones, D Capper, M Sill, ...
Cell 164 (5), 1060-1072, 2016
8262016
Accurate and efficient detection of gene fusions from RNA sequencing data
S Uhrig, J Ellermann, T Walther, P Burkhardt, M Fröhlich, B Hutter, ...
Genome research 31 (3), 448-460, 2021
2412021
NRG1 Fusions in KRAS Wild-Type Pancreatic Cancer
C Heining, P Horak, S Uhrig, PL Codo, B Klink, B Hutter, M Fröhlich, ...
Cancer discovery 8 (9), 1087-1095, 2018
2172018
Screening drug effects in patient‐derived cancer cells links organoid responses to genome alterations
J Jabs, FM Zickgraf, J Park, S Wagner, X Jiang, K Jechow, K Kleinheinz, ...
Molecular systems biology 13 (11), 955, 2017
2002017
Single-cell transcriptomic analyses provide insights into the developmental origins of neuroblastoma
S Jansky, AK Sharma, V Körber, A Quintero, UH Toprak, EM Wecht, ...
Nature genetics 53 (5), 683-693, 2021
1572021
Conserved peptide fragmentation as a benchmarking tool for mass spectrometers and a discriminating feature for targeted proteomics
UH Toprak, LC Gillet, A Maiolica, P Navarro, A Leitner, R Aebersold
Molecular & Cellular Proteomics 13 (8), 2056-2071, 2014
1232014
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
C López, K Kleinheinz, SM Aukema, M Rohde, SH Bernhart, ...
Nature communications 10 (1), 1459, 2019
1152019
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer
N Ishaque, ML Abba, C Hauser, N Patil, N Paramasivam, ...
Nature communications 9 (1), 4782, 2018
1142018
MYC/MIZ1-dependent gene repression inversely coordinates the circadian clock with cell cycle and proliferation
A Shostak, B Ruppert, N Ha, P Bruns, UH Toprak, R Eils, M Schlesner, ...
Nature communications 7 (1), 11807, 2016
1022016
Super enhancers define regulatory subtypes and cell identity in neuroblastoma
M Gartlgruber, AK Sharma, A Quintero, D Dreidax, S Jansky, YG Park, ...
Nature Cancer 2 (1), 114-128, 2021
972021
Mutational patterns and regulatory networks in epigenetic subgroups of meningioma
N Paramasivam, D Hübschmann, UH Toprak, N Ishaque, M Neidert, ...
Acta neuropathologica 138, 295-308, 2019
762019
The genomic and transcriptional landscape of primary central nervous system lymphoma
J Radke, N Ishaque, R Koll, Z Gu, E Schumann, L Sieverling, S Uhrig, ...
Nature Communications 13 (1), 2558, 2022
632022
IG-MYC+ neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas
R Wagener, C Lopez, K Kleinheinz, J Bausinger, SM Aukema, I Nagel, ...
Blood, The Journal of the American Society of Hematology 132 (21), 2280-2285, 2018
632018
Alternative lengthening of telomeres in childhood neuroblastoma from genome to proteome
SA Hartlieb, L Sieverling, M Nadler-Holly, M Ziehm, UH Toprak, ...
Nature communications 12 (1), 1269, 2021
622021
Modulation of the chromatin phosphoproteome by the Haspin protein kinase
A Maiolica, M de Medina-Redondo, EM Schoof, A Chaikuad, F Villa, ...
Molecular & cellular proteomics 13 (7), 1724-1740, 2014
522014
Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas
D Hübschmann, K Kleinheinz, R Wagener, SH Bernhart, C López, ...
Leukemia 35 (7), 2002-2016, 2021
512021
Therapeutic vulnerabilities in the DNA damage response for the treatment of ATRX mutant neuroblastoma
SL George, F Lorenzi, D King, S Hartlieb, J Campbell, H Pemberton, ...
EBioMedicine 59, 2020
482020
Globally altered epigenetic landscape and delayed osteogenic differentiation in H3. 3-G34W-mutant giant cell tumor of bone
P Lutsik, A Baude, D Mancarella, S Öz, A Kühn, R Toth, J Hey, UH Toprak, ...
Nature communications 11 (1), 5414, 2020
412020
Meningiomas induced by low-dose radiation carry structural variants of NF2 and a distinct mutational signature
F Sahm, UH Toprak, D Hübschmann, K Kleinheinz, I Buchhalter, M Sill, ...
Acta neuropathologica 134, 155-158, 2017
282017
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Artikelen 1–20