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Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease Q Zhou, H Wang, DM Schwartz, M Stoffels, YH Park, Y Zhang, D Yang, ... Nature genetics 48 (1), 67-73, 2016 | 548 | 2016 |
Identification of high-risk enterococcal clonal complexes: global dispersion and antibiotic resistance HL Leavis, MJM Bonten, RJL Willems Current opinion in microbiology 9 (5), 454-460, 2006 | 403 | 2006 |
A Novel Putative Enterococcal Pathogenicity Island Linked to the esp Virulence Gene of Enterococcus faecium and Associated with Epidemicity H Leavis, J Top, N Shankar, K Borgen, M Bonten, J van Embden, ... Journal of bacteriology 186 (3), 672-682, 2004 | 300 | 2004 |
A guide to immunotherapy for COVID-19 FL van de Veerdonk, E Giamarellos-Bourboulis, P Pickkers, L Derde, ... Nature medicine 28 (1), 39-50, 2022 | 264 | 2022 |
Insertion sequence–driven diversification creates a globally dispersed emerging multiresistant subspecies of E. faecium HL Leavis, RJL Willems, WJB van Wamel, FH Schuren, MPM Caspers, ... PLoS pathogens 3 (1), e7, 2007 | 238 | 2007 |
Restricted gene flow among hospital subpopulations of Enterococcus faecium RJL Willems, J Top, W van Schaik, H Leavis, M Bonten, J Sirén, ... MBio 3 (4), 10.1128/mbio. 00151-12, 2012 | 214 | 2012 |
A20 haploinsufficiency (HA20): clinical phenotypes and disease course of patients with a newly recognised NF-kB-mediated autoinflammatory disease FA Aeschlimann, ED Batu, SW Canna, E Go, A Gül, P Hoffmann, ... Annals of the rheumatic diseases 77 (5), 728-735, 2018 | 202 | 2018 |
Epidemic and nonepidemic multidrug-resistant Enterococcus faecium HL Leavis, RJL Willems, J Top, E Spalburg, EM Mascini, AC Fluit, ... Emerging infectious diseases 9 (9), 1108, 2003 | 155 | 2003 |
CD55 deficiency, early-onset protein-losing enteropathy, and thrombosis A Ozen, WA Comrie, RC Ardy, C Domínguez Conde, B Dalgic, ÖF Beser, ... New England Journal of Medicine 377 (1), 52-61, 2017 | 154 | 2017 |
High-Level Ciprofloxacin Resistance from Point Mutations in gyrA and parC Confined to Global Hospital-Adapted Clonal Lineage CC17 of Enterococcus faecium HL Leavis, RJL Willems, J Top, MJM Bonten Journal of clinical microbiology 44 (3), 1059-1064, 2006 | 152 | 2006 |
Phenotypic variability in patients with ADA2 deficiency due to identical homozygous R169Q mutations JM Van Montfrans, EAR Hartman, KPJ Braun, EAM Hennekam, EA Hak, ... Rheumatology 55 (5), 902-910, 2016 | 146 | 2016 |
Optimizing future treatment of enterococcal infections: attacking the biofilm? FL Paganelli, RJ Willems, HL Leavis Trends in microbiology 20 (1), 40-49, 2012 | 131 | 2012 |
Adult-onset autoinflammation caused by somatic mutations in UBA1: a Dutch case series of patients with VEXAS CI van der Made, J Potjewijd, A Hoogstins, HPJ Willems, AJ Kwakernaak, ... Journal of Allergy and Clinical Immunology 149 (1), 432-439. e4, 2022 | 129 | 2022 |
Long-term (180-day) outcomes in critically ill patients with COVID-19 in the REMAP-CAP randomized clinical trial S Florescu, D Stanciu, M Zaharia, A Kosa, D Codreanu, A Kidwai, ... Jama 329 (1), 39-51, 2023 | 82 | 2023 |
Effect of antiplatelet therapy on survival and organ support–free days in critically ill patients with COVID-19: a randomized clinical trial CA Bradbury, PR Lawler, SJ Stanworth, BJ McVerry, Z McQuilten, ... Jama 327 (13), 1247, 2022 | 79 | 2022 |
Roux-Y gastric bypass and sleeve gastrectomy directly change gut microbiota composition independent of surgery type FL Paganelli, M Luyer, CM Hazelbag, HW Uh, MRC Rogers, D Adriaans, ... Scientific reports 9 (1), 10979, 2019 | 75 | 2019 |
Microbial dysbiosis in common variable immune deficiencies: evidence, causes, and consequences RM Berbers, S Nierkens, JM Van Laar, D Bogaert, HL Leavis Trends in immunology 38 (3), 206-216, 2017 | 71 | 2017 |
Acute influenza virus-associated encephalitis and encephalopathy in adults: a challenging diagnosis WJ Meijer, FHH Linn, AMJ Wensing, HL Leavis, D van Riel, ... JMM Case reports 3 (6), e005076, 2016 | 65 | 2016 |